TY - JOUR
KW - Adolescent
KW - Adult
KW - BCG Vaccine
KW - Case-Control Studies
KW - Chi-Square Distribution
KW - Child
KW - Confidence Intervals
KW - Female
KW - Humans
KW - India
KW - leprosy
KW - Male
KW - Matched-Pair Analysis
KW - Odds Ratio
KW - Social Class
AU - Kulkarni H R
AU - Zodpey S P
AB - <p>For this paper we conducted a secondary data analysis to test the hypothesis that a linear trend exists in the protective effect of bacillus Calmette-Guerin (BCG) vaccine against types of leprosy. We used data from two previous case-control studies to perform an unmatched test for linear trend. We observed that both the studies revealed a significant linear trend (P<0.00001). One study that estimated an insignificant protective effect of BCG against paucibacillary leprosy showed a significant departure from linearity. We conclude that, the protective effect of BCG vaccination is differential across severity of leprosy as it brings about a shift in the immune response to a higher level of cell mediated immunity. We recommend that future studies dealing with the protective effect of BCG against leprosy should also conduct an analysis for trend.</p>
BT - Public health
C1 - http://www.ncbi.nlm.nih.gov/pubmed/10637526?dopt=Abstract
DA - 1999 Nov
DO - 10.1016/s0033-3506(99)00187-0
IS - 6
J2 - Public Health
LA - eng
N2 - <p>For this paper we conducted a secondary data analysis to test the hypothesis that a linear trend exists in the protective effect of bacillus Calmette-Guerin (BCG) vaccine against types of leprosy. We used data from two previous case-control studies to perform an unmatched test for linear trend. We observed that both the studies revealed a significant linear trend (P<0.00001). One study that estimated an insignificant protective effect of BCG against paucibacillary leprosy showed a significant departure from linearity. We conclude that, the protective effect of BCG vaccination is differential across severity of leprosy as it brings about a shift in the immune response to a higher level of cell mediated immunity. We recommend that future studies dealing with the protective effect of BCG against leprosy should also conduct an analysis for trend.</p>
PY - 1999
SP - 311
EP - 3
T2 - Public health
TI - Differential protective effect of bacillus Calmette-Guerin vaccine against multibacillary and paucibacillary leprosy in Nagpur, India.
VL - 113
SN - 0033-3506
ER -