The absence of an effective antileprosy vaccine, capable of preventing the spread of leprosy hinders its control in endemic countries. Developing such a vaccine is highly difficult due to the absence of reproducible methods for the in vitro cultivation of Mycobacterium leprae. The results of field trials of earlier proposed vaccines (BCG and BCG in combination with killed M. leprae) are indicative of their insufficient efficacy. The article presents a review of literature, including historical information, current problems and the main approaches to the development of vaccine against leprosy.
BT - Zhurnal mikrobiologii, epidemiologii, i immunobiologii C1 - http://www.ncbi.nlm.nih.gov/pubmed/15881952?dopt=Abstract DA - 2005 Mar-Apr IS - 2 J2 - Zh. Mikrobiol. Epidemiol. Immunobiol. LA - rus N2 -The absence of an effective antileprosy vaccine, capable of preventing the spread of leprosy hinders its control in endemic countries. Developing such a vaccine is highly difficult due to the absence of reproducible methods for the in vitro cultivation of Mycobacterium leprae. The results of field trials of earlier proposed vaccines (BCG and BCG in combination with killed M. leprae) are indicative of their insufficient efficacy. The article presents a review of literature, including historical information, current problems and the main approaches to the development of vaccine against leprosy.
PY - 2005 SP - 93 EP - 100 T2 - Zhurnal mikrobiologii, epidemiologii, i immunobiologii TI - [Development of antileprosy vaccines]. SN - 0372-9311 ER -