TY - JOUR
KW - Africa
KW - Americas
KW - Asia
KW - Biological Evolution
KW - Emigration and Immigration
KW - Europe
KW - Genes, Bacterial
KW - Genome, Bacterial
KW - History, 18th Century
KW - History, 19th Century
KW - History, Ancient
KW - History, Medieval
KW - Humans
KW - Interspersed Repetitive Sequences
KW - leprosy
KW - Minisatellite Repeats
KW - Mycobacterium leprae
KW - Oligonucleotide Array Sequence Analysis
KW - Polymorphism, Single Nucleotide
KW - Population Dynamics
KW - Pseudogenes
KW - Sequence Analysis, DNA
AU - Monot M
AU - Honore N
AU - Garnier T
AU - Araoz R
AU - Coppée J
AU - Lacroix C
AU - Sow S
AU - Spencer JS
AU - Truman RW
AU - Williams DL
AU - Gelber R
AU - Virmond M
AU - Flageul B
AU - Cho S
AU - Ji B
AU - Paniz-Mondolfi A
AU - Convit J
AU - Young S
AU - Fine PE
AU - Rasolofo V
AU - Brennan PJ
AU - Cole S
AB - <p>Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.</p>
BT - Science (New York, N.Y.)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15894530?dopt=Abstract
CN - MONOT 2005
DA - 2005 May 13
DO - 10.1126/science/1109759
IS - 5724
J2 - Science
LA - eng
N2 - <p>Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.</p>
PY - 2005
SP - 1040
EP - 2
T2 - Science (New York, N.Y.)
TI - On the origin of leprosy.
UR - http://science.sciencemag.org/content/308/5724/1040.full
VL - 308
SN - 1095-9203
ER -