TY - JOUR
KW - Cell Adhesion
KW - Concanavalin A
KW - Humans
KW - Immunoglobulin G
KW - Lepromin
KW - leprosy
KW - Lymphocyte Activation
KW - Lymphocytes
KW - Receptors, Fc
KW - Rosette Formation
KW - T-Lymphocytes, Regulatory
AU - Mehra V
AU - Mason L H
AU - Fields J P
AU - Bloom B R
AB - <p>The possibility of an active mechanism of immunologic suppression in leprosy was explored by assessing the in vitro lymphocyte responses of 61 leprosy patients and 30 normal individuals to the mitogen Con A in the presence or absence of Dharmendra lepromin. Lepromin-induced suppression of Con A stimulation was found in 32 of 35 lepromatous patients and 15 of 15 borderline patients, but only 2 of 15 tuberculoid patients and 2 of 30 normal controls. Cell fractionation studies indicated at least two cell populations involved in the in vitro lepromin-induced suppressor activity, adherent cells and T gamma-cells.</p>
BT - Journal of immunology (Baltimore, Md. : 1950)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/158056?dopt=Abstract
DA - 1979 Oct
IS - 4
J2 - J. Immunol.
LA - eng
N2 - <p>The possibility of an active mechanism of immunologic suppression in leprosy was explored by assessing the in vitro lymphocyte responses of 61 leprosy patients and 30 normal individuals to the mitogen Con A in the presence or absence of Dharmendra lepromin. Lepromin-induced suppression of Con A stimulation was found in 32 of 35 lepromatous patients and 15 of 15 borderline patients, but only 2 of 15 tuberculoid patients and 2 of 30 normal controls. Cell fractionation studies indicated at least two cell populations involved in the in vitro lepromin-induced suppressor activity, adherent cells and T gamma-cells.</p>
PY - 1979
SP - 1813
EP - 7
T2 - Journal of immunology (Baltimore, Md. : 1950)
TI - Lepromin-induced suppressor cells in patients with leprosy.
VL - 123
SN - 0022-1767
ER -