TY - JOUR KW - Animals KW - Anti-Bacterial Agents KW - Drug Therapy, Combination KW - Kidney KW - Leprostatic Agents KW - leprosy KW - Liver KW - Male KW - Minocycline KW - Ofloxacin KW - Rats KW - Rats, Wistar KW - Rifampin AU - Malfará WR AU - Uyemura SA AU - Queiroz RHC AB -

Leprosy, a chronic granulomatous infectocontagious disease transmitted by Mycobacterium leprae, continues to be prevalent today, especially in underdeveloped countries and its paucibacillary form with a single lesion is being treated with rifampicin (600mg), ofloxacin (400mg) and minocycline (100mg) administered as a single dose (ROM scheme). Thus, the objective of the present study was to investigate the dose/plasma concentration correlation versus biochemical changes occurring in male Wistar rats receiving a single dose of rifampicin, ofloxacin and minocycline in mono- and polytherapy. Rifampicin and ofloxacin showed an increased concentration in plasma when administered in polytherapy, whereas minocycline was reduced, probably due to interference with its biotransformation and excretion. Biochemical analyses showed that rifampicin is probably responsible for hepatic and renal changes and that the medicamentous interactions involving the drug require individualized studies, especially when the drug is associated with ofloxacin and minocycline therapy.

BT - Revista da Sociedade Brasileira de Medicina Tropical C1 - http://www.ncbi.nlm.nih.gov/pubmed/15821793?dopt=Abstract DA - 2005 Mar-Apr DO - 10.1590/s0037-86822005000200008 IS - 2 J2 - Rev. Soc. Bras. Med. Trop. LA - por N2 -

Leprosy, a chronic granulomatous infectocontagious disease transmitted by Mycobacterium leprae, continues to be prevalent today, especially in underdeveloped countries and its paucibacillary form with a single lesion is being treated with rifampicin (600mg), ofloxacin (400mg) and minocycline (100mg) administered as a single dose (ROM scheme). Thus, the objective of the present study was to investigate the dose/plasma concentration correlation versus biochemical changes occurring in male Wistar rats receiving a single dose of rifampicin, ofloxacin and minocycline in mono- and polytherapy. Rifampicin and ofloxacin showed an increased concentration in plasma when administered in polytherapy, whereas minocycline was reduced, probably due to interference with its biotransformation and excretion. Biochemical analyses showed that rifampicin is probably responsible for hepatic and renal changes and that the medicamentous interactions involving the drug require individualized studies, especially when the drug is associated with ofloxacin and minocycline therapy.

PY - 2005 SP - 167 EP - 72 T2 - Revista da Sociedade Brasileira de Medicina Tropical TI - [Correlation between dose/plasma concentration and assessment of hepatic and renal changes in Wistar rats treated with the ROM scheme]. VL - 38 SN - 0037-8682 ER -