TY - JOUR
KW - Arthritis
KW - Cicatrix
KW - Clofazimine
KW - Dose-Response Relationship, Drug
KW - Drug-Related Side Effects and Adverse Reactions
KW - Edema
KW - Erythema
KW - Erythema Nodosum
KW - Foot
KW - Glucocorticoids
KW - Hand
KW - Humans
KW - Hypersensitivity
KW - Immunosuppressive Agents
KW - leprosy
KW - Lymphadenitis
KW - Neuritis
KW - Paralysis
KW - Prednisolone
KW - Skin
KW - Thalidomide
KW - Treatment Outcome
AU - Ganapati R
AU - Pai V V
AB - <p>The uneventful response to chemotherapy in leprosy is marked by clinically disturbing episodes encountered in 20-30% of patients and these phenomena are called "reactions". Generally they are classified as reversal reaction (type-1) and erythema nodosum leprosum (type-2). The cutaneous menifestations are: (1) Type-2 reactions in LL, BL types constituting erythema nodosum leprosum, erythema multiforme, erythema necroticans, subcutaneous nodules, lepromatous exacerbation. (2) Type-1 reactions in borderline and tuberculoid leprosy. The other manifestations include: Acute neuritis, lymphadenitis, arthritis, oedema of the hands and feet, ocular lesions, etc. Sequelae of reactions are: Paralytic deformities, non-paralytic deformities, extensive scarring and renal damage. A simple guideline to identify the risk-prone cases has been narrated. Prednisolone in standard dosage schedule as recommended by WHO is now being widely used in control programmes.</p>
BT - Journal of the Indian Medical Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15871353?dopt=Abstract
CN - GANAPATI 2004
DA - 2004 Dec
IS - 12
J2 - J Indian Med Assoc
LA - eng
N2 - <p>The uneventful response to chemotherapy in leprosy is marked by clinically disturbing episodes encountered in 20-30% of patients and these phenomena are called "reactions". Generally they are classified as reversal reaction (type-1) and erythema nodosum leprosum (type-2). The cutaneous menifestations are: (1) Type-2 reactions in LL, BL types constituting erythema nodosum leprosum, erythema multiforme, erythema necroticans, subcutaneous nodules, lepromatous exacerbation. (2) Type-1 reactions in borderline and tuberculoid leprosy. The other manifestations include: Acute neuritis, lymphadenitis, arthritis, oedema of the hands and feet, ocular lesions, etc. Sequelae of reactions are: Paralytic deformities, non-paralytic deformities, extensive scarring and renal damage. A simple guideline to identify the risk-prone cases has been narrated. Prednisolone in standard dosage schedule as recommended by WHO is now being widely used in control programmes.</p>
PY - 2004
SP - 688
EP - 90
EP - 692
EP - 694
T2 - Journal of the Indian Medical Association
TI - Reactions and their management.
VL - 102
SN - 0019-5847
ER -