An ambulatory treatment regimen for multibacillary leprosy, of 34 weeks duration composed of 8 weeks daily supervised rifampicin, ethionamide (ETH), dapsone (DDS) and clofazimine (CLO) followed by 26 weeks of unsupervised ETH, DDS and CLO, introduced in 1983 has been evaluated; 268 patients were followed for a mean of 4.4 years and a total of 1188 patient years. The relapse rate was 0.33 per 100 patient years of follow up. The reduction of the duration of the combined administration of RMP + ETH reduced the hepatotoxicity to 1.4%. It is possible that both phases of the regimen studied could still be reduced, however, in the near future ETH will be replaced by alternative bactericidal drugs, avoiding the hepatotoxicity.
BT - Leprosy review C1 - http://www.ncbi.nlm.nih.gov/pubmed/1569814?dopt=Abstract CN - Infolep Library - available DA - 1992 Mar DO - 10.5935/0305-7518.19920006 IS - 1 J2 - Lepr Rev LA - eng N2 -An ambulatory treatment regimen for multibacillary leprosy, of 34 weeks duration composed of 8 weeks daily supervised rifampicin, ethionamide (ETH), dapsone (DDS) and clofazimine (CLO) followed by 26 weeks of unsupervised ETH, DDS and CLO, introduced in 1983 has been evaluated; 268 patients were followed for a mean of 4.4 years and a total of 1188 patient years. The relapse rate was 0.33 per 100 patient years of follow up. The reduction of the duration of the combined administration of RMP + ETH reduced the hepatotoxicity to 1.4%. It is possible that both phases of the regimen studied could still be reduced, however, in the near future ETH will be replaced by alternative bactericidal drugs, avoiding the hepatotoxicity.
PY - 1992 SP - 36 EP - 40 T2 - Leprosy review TI - Ambulatory treatment of multibacillary leprosy with a regimen of 8 months duration. UR - http://leprev.ilsl.br/pdfs/1992/v63n1/pdf/v63n1a06.pdf VL - 63 SN - 0305-7518 ER -