The relation between diaminodiphenylsulfone (called dapsone)-resistance and point mutations of the dihydropteroate synthase (DHPS) gene was analyzed using dapsone resistant Mycobacterium leprae isolates derived from Japanese leprosy patients. The mutation was found at amino acid residues 53 or 55 of the DHPS. This finding suggests that two specific mutations in the DHPS gene involved in dapsone resistance of M. leprae.
BT - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association C1 - http://www.ncbi.nlm.nih.gov/pubmed/15508724?dopt=Abstract DA - 2004 Sep IS - 3 J2 - Nihon Hansenbyo Gakkai Zasshi LA - jpn N2 -The relation between diaminodiphenylsulfone (called dapsone)-resistance and point mutations of the dihydropteroate synthase (DHPS) gene was analyzed using dapsone resistant Mycobacterium leprae isolates derived from Japanese leprosy patients. The mutation was found at amino acid residues 53 or 55 of the DHPS. This finding suggests that two specific mutations in the DHPS gene involved in dapsone resistance of M. leprae.
PY - 2004 SP - 221 EP - 6 T2 - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association TI - [Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene]. VL - 73 SN - 1342-3681 ER -