TY - JOUR
KW - Animals
KW - Base Sequence
KW - Dapsone
KW - DNA gyrase
KW - DNA-Directed RNA Polymerases
KW - Drug Resistance, Multiple
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Mutation
KW - Mycobacterium leprae
KW - Ofloxacin
KW - Rifampin
AU - Maeda S
AB - <p>DNA sequences of Mycobacterium leprae in particular regions of the gyrA, rpoB, and folP genes responsible for resistance to new quinolones, rifampicin and dapsone, respectively, were analyzed. Among 88 isolates of M. leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines, eleven isolates had mutational changes in 2 genes (resistance to 2 drugs), and 2 isolates (Shinsei-1 and Zensho-4) showed mutations in 3 genes (resistance to 3 drugs). These findings are suggesting emergence of multi-drug resistant M. leprae.</p>
BT - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15508725?dopt=Abstract
DA - 2004 Sep
IS - 3
J2 - Nihon Hansenbyo Gakkai Zasshi
LA - jpn
N2 - <p>DNA sequences of Mycobacterium leprae in particular regions of the gyrA, rpoB, and folP genes responsible for resistance to new quinolones, rifampicin and dapsone, respectively, were analyzed. Among 88 isolates of M. leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines, eleven isolates had mutational changes in 2 genes (resistance to 2 drugs), and 2 isolates (Shinsei-1 and Zensho-4) showed mutations in 3 genes (resistance to 3 drugs). These findings are suggesting emergence of multi-drug resistant M. leprae.</p>
PY - 2004
SP - 227
EP - 33
T2 - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
TI - [Multi-drug resistant Mycobacterium leprae from patients with leprosy].
VL - 73
SN - 1342-3681
ER -