As an obligate intracellular pathogen, the principal host cells for Mycobacterium leprae are mononuclear phagocytes or macrophages. The macrophage is a primitive cell type being found in both early and advanced life forms, and possesses a variety of functions, such as phagocytosis of invaded bacteria, production of cytokines, antigen presentation and tumor killing. Hansen's disease is a chronic infectious disease characterized by specific host immune responses against M. leprae. In this article the macrophage is focused to dissect its functions in the disease.
BT - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association C1 - http://www.ncbi.nlm.nih.gov/pubmed/15508728?dopt=Abstract DA - 2004 Sep IS - 3 J2 - Nihon Hansenbyo Gakkai Zasshi LA - jpn N2 -As an obligate intracellular pathogen, the principal host cells for Mycobacterium leprae are mononuclear phagocytes or macrophages. The macrophage is a primitive cell type being found in both early and advanced life forms, and possesses a variety of functions, such as phagocytosis of invaded bacteria, production of cytokines, antigen presentation and tumor killing. Hansen's disease is a chronic infectious disease characterized by specific host immune responses against M. leprae. In this article the macrophage is focused to dissect its functions in the disease.
PY - 2004 SP - 253 EP - 61 T2 - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association TI - [Functional changes of macrophages in Hansen's disease]. VL - 73 SN - 1342-3681 ER -