TY - JOUR
KW - Antigens, CD
KW - Case-Control Studies
KW - Glycoproteins
KW - Humans
KW - Immunoglobulins
KW - Interferon-gamma
KW - leprosy
KW - Leprosy, Tuberculoid
KW - Receptors, Cell Surface
KW - RNA, Messenger
KW - Signaling Lymphocytic Activation Molecule Family Member 1
KW - Th1 Cells
KW - Th2 Cells
AU - Quiroga MF
AU - Martínez G
AU - Pasquinelli V
AU - García VE
AB - <p>The SLAM-associated protein (SAP) regulates IFN-gamma expression in leprosy. Tuberculoid leprosy patients locally produce Th1 cytokines, while lepromatous patients produce Th2 cytokines. Signaling lymphocytic activation molecule (SLAM) and the SLAM-associated protein (SAP) participate in the differentiation process that leads to the production of specific patterns of cytokines by activated T cells. To investigate the SLAM/SAP pathway in M. leprae infection, we determined the expression of SAP, IFN-gamma and SLAM RNA messenger in leprosy patients. We found a direct correlation of SLAM expression with IFN-gamma expression, whereas the expression of SAP was inversely correlated with the expression of both SLAM and IFN-gamma. Therefore, our data indicate that SAP might interfere with Th1 cytokine responses while SLAM expression may contribute to Th1 responses in leprosy. This study further suggests that the SLAM/SAP pathway might be a focal point for therapeutic modulation of T cell cytokine responses in diseases characterized by dysfunctional Th2 responses.</p>
BT - Medicina
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15560546?dopt=Abstract
DA - 2004
IS - 5
J2 - Medicina (B Aires)
LA - spa
N2 - <p>The SLAM-associated protein (SAP) regulates IFN-gamma expression in leprosy. Tuberculoid leprosy patients locally produce Th1 cytokines, while lepromatous patients produce Th2 cytokines. Signaling lymphocytic activation molecule (SLAM) and the SLAM-associated protein (SAP) participate in the differentiation process that leads to the production of specific patterns of cytokines by activated T cells. To investigate the SLAM/SAP pathway in M. leprae infection, we determined the expression of SAP, IFN-gamma and SLAM RNA messenger in leprosy patients. We found a direct correlation of SLAM expression with IFN-gamma expression, whereas the expression of SAP was inversely correlated with the expression of both SLAM and IFN-gamma. Therefore, our data indicate that SAP might interfere with Th1 cytokine responses while SLAM expression may contribute to Th1 responses in leprosy. This study further suggests that the SLAM/SAP pathway might be a focal point for therapeutic modulation of T cell cytokine responses in diseases characterized by dysfunctional Th2 responses.</p>
PY - 2004
SP - 436
EP - 8
T2 - Medicina
TI - [The SLAM-associated protein (SAP) regulates IFN-gamma expression in leprosy].
VL - 64
SN - 0025-7680
ER -