TY - JOUR
KW - AIDS-Related Opportunistic Infections
KW - Anti-HIV Agents
KW - Autoimmune Diseases
KW - Diagnosis, Differential
KW - Female
KW - HIV Infections
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Middle Aged
AU - Couppié P
AU - Abel S
AU - Voinchet H
AU - Roussel M
AU - Hélénon R
AU - Huerre M
AU - Sainte-Marie D
AU - Cabié A
AB - <p><b>BACKGROUND: </b>Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction to an opportunistic infection that occurs in human immunodeficiency virus (HIV)-positive patients with profound immunosuppression during the reconstitution of the immune system in the initial months of highly active antiretroviral treatment.</p><p><b>OBSERVATIONS: </b>We describe 3 cases of leprosy occurring in patients treated with a combination of 3 antiretroviral drugs who fulfilled the criteria for IRIS. A reactional state occurred in all 3 cases. Two of the 3 patients presented an unusual ulcerous progression of the lesions not generally observed in cases of leprosy. The outcome was favorable in all 3 cases. The frequency of IRIS associated with leprosy in French Guiana and Martinique is estimated at 3 cases per 1000 HIV-positive patients receiving highly active antiretroviral treatment.</p><p><b>CONCLUSION: </b>Leprosy should be recognized as an IRIS-associated infection with possibility of atypical presentation.</p>
BT - Archives of dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15313818?dopt=Abstract
CN - COUPPIE2004
DA - 2004 Aug
DO - 10.1001/archderm.140.8.997
IS - 8
J2 - Arch Dermatol
LA - eng
N2 - <p><b>BACKGROUND: </b>Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction to an opportunistic infection that occurs in human immunodeficiency virus (HIV)-positive patients with profound immunosuppression during the reconstitution of the immune system in the initial months of highly active antiretroviral treatment.</p><p><b>OBSERVATIONS: </b>We describe 3 cases of leprosy occurring in patients treated with a combination of 3 antiretroviral drugs who fulfilled the criteria for IRIS. A reactional state occurred in all 3 cases. Two of the 3 patients presented an unusual ulcerous progression of the lesions not generally observed in cases of leprosy. The outcome was favorable in all 3 cases. The frequency of IRIS associated with leprosy in French Guiana and Martinique is estimated at 3 cases per 1000 HIV-positive patients receiving highly active antiretroviral treatment.</p><p><b>CONCLUSION: </b>Leprosy should be recognized as an IRIS-associated infection with possibility of atypical presentation.</p>
PY - 2004
SP - 997
EP - 1000
T2 - Archives of dermatology
TI - Immune reconstitution inflammatory syndrome associated with HIV and leprosy.
VL - 140
SN - 0003-987X
ER -