The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.
BT - Current opinion in immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/15245748?dopt=Abstract CN - RAMBUKKANA 2004 DA - 2004 Aug DO - 10.1016/j.coi.2004.05.021 IS - 4 J2 - Curr. Opin. Immunol. LA - eng N2 -The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.
PY - 2004 SP - 511 EP - 8 T2 - Current opinion in immunology TI - Mycobacterium leprae-induced demyelination: a model for early nerve degeneration. VL - 16 SN - 0952-7915 ER -