TY - JOUR
KW - Agglutination Tests
KW - Antibodies, Bacterial
KW - Antigens, Bacterial
KW - Glycolipids
KW - Humans
KW - Latex
KW - leprosy
KW - Microspheres
KW - Mycobacterium leprae
KW - Sensitivity and Specificity
AU - Vaishnavi C
AU - Agnihotri N
AU - Kumar B
AU - Kaur S
AU - Ganguly N K
AB - <p>Serum samples were collected from eighty-three leprosy patients and twenty-five healthy controls supposedly not exposed to Mycobacterium leprae infection. Phenolic glycolipid-1 coated latex agglutination test (PGL-LAT) was carried out with the serum samples to detect antibodies specific to M. leprae. Samples showing positive agglutination were 50% in the lepromatous leprosy (LL) group showing no erythema nodosum leprosum (ENL) complications, 66.6% in LL group with ENL complication, 60% in borderline lepromatous (BL) group, 50% in borderline (BB) and 33.3% in borderline tuberculoid (BT). The patients belonging to the tuberculoid (TT) group and most of the long-term treated patients were interestingly negative, and so were sera from all the healthy controls. PGL-LAT developed by us therefore is specific and a fairly sensitive technique to detect antibodies specific to M. leprae and will be very useful in field conditions.</p>
BT - Journal of hygiene, epidemiology, microbiology, and immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1512452?dopt=Abstract
DA - 1992
IS - 2
J2 - J Hyg Epidemiol Microbiol Immunol
LA - eng
N2 - <p>Serum samples were collected from eighty-three leprosy patients and twenty-five healthy controls supposedly not exposed to Mycobacterium leprae infection. Phenolic glycolipid-1 coated latex agglutination test (PGL-LAT) was carried out with the serum samples to detect antibodies specific to M. leprae. Samples showing positive agglutination were 50% in the lepromatous leprosy (LL) group showing no erythema nodosum leprosum (ENL) complications, 66.6% in LL group with ENL complication, 60% in borderline lepromatous (BL) group, 50% in borderline (BB) and 33.3% in borderline tuberculoid (BT). The patients belonging to the tuberculoid (TT) group and most of the long-term treated patients were interestingly negative, and so were sera from all the healthy controls. PGL-LAT developed by us therefore is specific and a fairly sensitive technique to detect antibodies specific to M. leprae and will be very useful in field conditions.</p>
PY - 1992
SP - 169
EP - 73
T2 - Journal of hygiene, epidemiology, microbiology, and immunology
TI - Field utility of phenolic glycolipid coated latex agglutination test for rapid detection of bacilliferous leprosy cases.
VL - 36
SN - 0022-1732
ER -