TY - JOUR
KW - Antigen Presentation
KW - Antigens, CD
KW - Antigens, CD1
KW - Antigens, Surface
KW - Cell Division
KW - Dose-Response Relationship, Drug
KW - Epidermis
KW - Fetal Blood
KW - Humans
KW - Immunohistochemistry
KW - Langerhans Cells
KW - Lectins
KW - Lectins, C-Type
KW - leprosy
KW - Mannose-Binding Lectins
KW - Microscopy, Fluorescence
KW - Mycobacterium leprae
KW - Phenotype
KW - Receptors, Antigen
KW - T-Lymphocytes
AU - Hunger R
AU - Sieling PA
AU - Ochoa MT
AU - Sugaya M
AU - Burdick A
AU - Rea T
AU - Brennan PJ
AU - Belisle JT
AU - Blauvelt A
AU - Porcelli SA
AU - Modlin RL
AB - <p>Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.</p>
BT - The Journal of clinical investigation
C1 - http://www.ncbi.nlm.nih.gov/pubmed/14991068?dopt=Abstract
DA - 2004 Mar
DO - 10.1172/JCI19655
IS - 5
J2 - J. Clin. Invest.
LA - eng
N2 - <p>Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.</p>
PY - 2004
SP - 701
EP - 8
T2 - The Journal of clinical investigation
TI - Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.
VL - 113
SN - 0021-9738
ER -