TY - JOUR
KW - Chromosomes, Human, Pair 21
KW - Female
KW - Genetic Linkage
KW - Genetic Predisposition to Disease
KW - Humans
KW - leprosy
KW - Malawi
KW - Male
KW - Pedigree
KW - Regression Analysis
AU - Wallace C
AU - Fitness J
AU - Hennig B
AU - Sichali L
AU - Mwaungulu L
AU - Ponnighaus J M
AU - Warndorff D K
AU - Clayton D
AU - Fine PE
AU - Hill A V S
AB - <p>Leprosy is a chronic disease caused by infection with Mycobacterium leprae, which is manifested across a wide clinical spectrum. There is evidence that susceptibility both to leprosy per se and to the clinical type of leprosy is influenced by host genetic factors. This paper describes the application of an identity by descent regression search for genetic determinants of leprosy type among families from Karonga District, Northern Malawi. Suggestive evidence was found for linkage to leprosy type on chr 21q22 (P<0.001). The methodological implications of the approach and the findings are discussed.</p>
BT - Genes and immunity
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15014432?dopt=Abstract
CN - WALLACE 2004
DA - 2004 May
DO - 10.1038/sj.gene.6364062
IS - 3
J2 - Genes Immun.
LA - eng
N2 - <p>Leprosy is a chronic disease caused by infection with Mycobacterium leprae, which is manifested across a wide clinical spectrum. There is evidence that susceptibility both to leprosy per se and to the clinical type of leprosy is influenced by host genetic factors. This paper describes the application of an identity by descent regression search for genetic determinants of leprosy type among families from Karonga District, Northern Malawi. Suggestive evidence was found for linkage to leprosy type on chr 21q22 (P<0.001). The methodological implications of the approach and the findings are discussed.</p>
PY - 2004
SP - 221
EP - 5
T2 - Genes and immunity
TI - Linkage analysis of susceptibility to leprosy type using an IBD regression method.
UR - http://www.nature.com/gene/journal/v5/n3/pdf/6364062a.pdf
VL - 5
SN - 1466-4879
ER -