Sera from 25 patients with type 1 (Lepra), upgrading and downgrading, and type 2 (erythema nodosum leprosum [ENL]) reactions were assayed, during the reaction and after its clinical remission, for changes in levels of alpha-1-antitrypsin (A1A) and C-reactive protein (CRP). The results were compared with those from normal healthy adults and patients of leprosy without history and/or clinical evidence of reaction. The A1A levels correlated better with changes in status of type 1 reaction; whereas CRP levels correlated well with alterations in type 2 reactions and were definitely superior to A1A in this situation for monitoring the course of these episodes.
BT - International journal of dermatology C1 - http://www.ncbi.nlm.nih.gov/pubmed/1459760?dopt=Abstract DA - 1992 Sep DO - 10.1111/j.1365-4362.1992.tb03981.x IS - 9 J2 - Int. J. Dermatol. LA - eng N2 -Sera from 25 patients with type 1 (Lepra), upgrading and downgrading, and type 2 (erythema nodosum leprosum [ENL]) reactions were assayed, during the reaction and after its clinical remission, for changes in levels of alpha-1-antitrypsin (A1A) and C-reactive protein (CRP). The results were compared with those from normal healthy adults and patients of leprosy without history and/or clinical evidence of reaction. The A1A levels correlated better with changes in status of type 1 reaction; whereas CRP levels correlated well with alterations in type 2 reactions and were definitely superior to A1A in this situation for monitoring the course of these episodes.
PY - 1992 SP - 632 EP - 4 T2 - International journal of dermatology TI - Reaction in leprosy: acute phase reactant response during and after remission. VL - 31 SN - 0011-9059 ER -