Rabbits, rats and guinea-pigs were treated with di(p-aminophenyl) sulphoxide and their urines examined by an analytical method which permits the simultaneous determination of this compound and of dapsone [di(p-aminophenyl) sulphone] which is a possible product of metabolic oxidation. The method gives for each drug the total of free compound plus acid-labile conjugates. All three species excreted unchanged drug together with dapsone. With rats and guinea-pigs about 33% of the excretion is dapsone, but with rabbits only 6 to 12%. The rate of combined excretion is much greater in rabbits than in the other two species. These results are discussed in relation to the significance of di(p-aminophenyl) sulphoxide as a drug in the treatment of leprosy.
BT - British journal of pharmacology and chemotherapy C1 - http://www.ncbi.nlm.nih.gov/pubmed/14416172?dopt=Abstract DA - 1960 Mar DO - 10.1111/j.1476-5381.1960.tb01225.x J2 - Br J Pharmacol Chemother LA - eng N2 -Rabbits, rats and guinea-pigs were treated with di(p-aminophenyl) sulphoxide and their urines examined by an analytical method which permits the simultaneous determination of this compound and of dapsone [di(p-aminophenyl) sulphone] which is a possible product of metabolic oxidation. The method gives for each drug the total of free compound plus acid-labile conjugates. All three species excreted unchanged drug together with dapsone. With rats and guinea-pigs about 33% of the excretion is dapsone, but with rabbits only 6 to 12%. The rate of combined excretion is much greater in rabbits than in the other two species. These results are discussed in relation to the significance of di(p-aminophenyl) sulphoxide as a drug in the treatment of leprosy.
PY - 1960 SP - 160 EP - 4 T2 - British journal of pharmacology and chemotherapy TI - Metabolism and excretion of di(p-aminophenyl) sulphoxide in different animal species. VL - 15 SN - 0366-0826 ER -