TY - JOUR KW - Adult KW - Aged KW - Biopsy KW - Drug Administration Schedule KW - Female KW - Humans KW - Injections, Intralesional KW - Interferon-gamma KW - Leprosy, lepromatous KW - Male KW - Middle Aged KW - Recombinant Proteins KW - Skin KW - Time Factors AU - Bottasso O AU - Besuschio S AU - Merlin V AU - Morini J C AU - Bernabo J AU - Falcoff R AU - Falcoff E AB -

We report on the histologic changes occurring in single cutaneous lesions, from six active lepromatous patients, 1 week following the administration of three daily intradermal injections, 35 micrograms each, of recombinant interferon gamma (rIFN-gamma). Except for a strong induration at the injection site, rIFN-gamma produced no adverse systemic reactions and was able to promote a remarkable influx of T-lymphocytes, mononuclear phagocytes with large nuclei, nonvacuolated cytoplasm, and reduced lysozyme reactivity. Furthermore, despite no clear-cut reduction of mycobacterial dermal burden, bacilli showed a clear increase in the granular appearance. Present findings provide a basis for further elucidation of rIFN-gamma as an additional tool for leprosy treatment.

BT - International journal of dermatology C1 - http://www.ncbi.nlm.nih.gov/pubmed/1428437?dopt=Abstract DA - 1992 Nov DO - 10.1111/j.1365-4362.1992.tb04253.x IS - 11 J2 - Int. J. Dermatol. LA - eng N2 -

We report on the histologic changes occurring in single cutaneous lesions, from six active lepromatous patients, 1 week following the administration of three daily intradermal injections, 35 micrograms each, of recombinant interferon gamma (rIFN-gamma). Except for a strong induration at the injection site, rIFN-gamma produced no adverse systemic reactions and was able to promote a remarkable influx of T-lymphocytes, mononuclear phagocytes with large nuclei, nonvacuolated cytoplasm, and reduced lysozyme reactivity. Furthermore, despite no clear-cut reduction of mycobacterial dermal burden, bacilli showed a clear increase in the granular appearance. Present findings provide a basis for further elucidation of rIFN-gamma as an additional tool for leprosy treatment.

PY - 1992 SP - 813 EP - 7 T2 - International journal of dermatology TI - Lepromatous leprosy treated with recombinant interferon gamma: cutaneous histologic changes. VL - 31 SN - 0011-9059 ER -