TY - JOUR KW - Antibody Formation KW - Cyclophosphamide KW - Dapsone KW - Immunochemistry KW - leprosy KW - Leukocyte Count KW - Leukopenia KW - Pharmacology KW - South Africa KW - Streptomycin KW - toxicology AU - Davison A R AU - Schulz E J AU - Falkson G AU - Egnal M L AB -

Cyclophosphamide is a propylene phosphoric ester diamide which is used in the treatment of neoplasms, though it is limited by the development of leucopenia. One of the authors (G. Falkson), in 1960, saw a leprosy patient who had been given Cyclophosphamide because of mistaken diagnosis of mycosis fungoides. The dermal infiltration and the neuritic symptoms of the leprosy patient had diminished with treatment. Accordingly 8 Bantu patients, at Westfort Institution, Pretoria, were given Cyclophosphamide intravenously in doses varying from 400 to 800 mgm. daily, followed, in 4 patients, by 100 mgm. daily by mouth. In 4 patients who received dapsone together with Cyclophosphamide, the leucopenic effect of the latter was inhibited. There was 1 patient with lepromatous leprosy who received only Cyclophosphamide for a long time; he benefited considerably. There is evidence that Cyclophosphamide may inhibit acute reactions in leprosy. The results are tabulated.

BT - Lancet (London, England) C1 - http://www.ncbi.nlm.nih.gov/pubmed/14213568?dopt=Abstract DA - 1964 Nov 28 DO - 10.1016/s0140-6736(64)92664-9 IS - 7370 J2 - Lancet LA - eng N2 -

Cyclophosphamide is a propylene phosphoric ester diamide which is used in the treatment of neoplasms, though it is limited by the development of leucopenia. One of the authors (G. Falkson), in 1960, saw a leprosy patient who had been given Cyclophosphamide because of mistaken diagnosis of mycosis fungoides. The dermal infiltration and the neuritic symptoms of the leprosy patient had diminished with treatment. Accordingly 8 Bantu patients, at Westfort Institution, Pretoria, were given Cyclophosphamide intravenously in doses varying from 400 to 800 mgm. daily, followed, in 4 patients, by 100 mgm. daily by mouth. In 4 patients who received dapsone together with Cyclophosphamide, the leucopenic effect of the latter was inhibited. There was 1 patient with lepromatous leprosy who received only Cyclophosphamide for a long time; he benefited considerably. There is evidence that Cyclophosphamide may inhibit acute reactions in leprosy. The results are tabulated.

PY - 1964 SP - 1138 EP - 41 T2 - Lancet (London, England) TI - Effect of Cyclophosphamide on Leprosy. Competitive Action of Cyclophosphamide and Dapsone. VL - 2 SN - 0140-6736 ER -