TY - JOUR
KW - Adult
KW - Animals
KW - Dapsone
KW - Drug Resistance, Microbial
KW - Female
KW - Humans
KW - leprosy
KW - Male
KW - Mice
KW - Mycobacterium leprae
AU - Bhatia V N
AU - Balakrishnan S
AU - Seshadri P S
AU - Neelan P N
AU - Roy R G
AB - <p>The Central Leprosy Teaching and Research Institute (C.L.T. & R.I.) Chengalpattu, took up studies on dapsone resistance in M. leprae from 1974. From 1978, the study was further strengthened by a project under THELEP (TDR) for eliciting information on the efficacy of certain drug regimens. The Thelep studies were to be conducted only on the dapsone sensitive untreated cases and, therefore, directed towards the detection of primary resistance, while the non-THELEP institutional studies were concentrated on secondary dapsone resistance problem. These two studies together detected 99 cases of dapsone resistance in the patients who attended CLTRI Hospital during 1974-81; 23 of them, were of primary origin, 16, 6 and 1 showing mild (RI), moderate (RII), and high (RIII) grades respectively. Of the remaining 76 cases of secondary resistance, 7 and 69 were of RII and RIII grades respectively. The need for vertical and horizontal monitoring of the drug resistance problem has been pointed out.</p>
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6396340?dopt=Abstract
CN - Infolep Library - available
DA - 1984 Jul-Sep
IS - 3
J2 - Indian J Lepr
LA - eng
N2 - <p>The Central Leprosy Teaching and Research Institute (C.L.T. & R.I.) Chengalpattu, took up studies on dapsone resistance in M. leprae from 1974. From 1978, the study was further strengthened by a project under THELEP (TDR) for eliciting information on the efficacy of certain drug regimens. The Thelep studies were to be conducted only on the dapsone sensitive untreated cases and, therefore, directed towards the detection of primary resistance, while the non-THELEP institutional studies were concentrated on secondary dapsone resistance problem. These two studies together detected 99 cases of dapsone resistance in the patients who attended CLTRI Hospital during 1974-81; 23 of them, were of primary origin, 16, 6 and 1 showing mild (RI), moderate (RII), and high (RIII) grades respectively. Of the remaining 76 cases of secondary resistance, 7 and 69 were of RII and RIII grades respectively. The need for vertical and horizontal monitoring of the drug resistance problem has been pointed out.</p>
PY - 1984
SP - 587
EP - 94
T2 - Indian journal of leprosy
TI - Dapsone resistance in patients attending Central Leprosy Teaching and Research Institute, Chengalpattu (South India).
VL - 56
SN - 0254-9395
ER -