TY - JOUR KW - Dapsone KW - Drug Resistance, Bacterial KW - Drug Resistance, Multiple KW - Drug Therapy, Combination KW - Humans KW - Leprostatic Agents KW - leprosy KW - Male KW - Middle Aged KW - Rifampin AU - Norman G AU - Joseph G AU - Ebenezer G AU - Rao SP AU - Job CK AB -
This is the first report of secondary resistance to rifampin following MDT in a patient with prolonged, but irregular treatment. Repeated mouse foot-pad studies demonstrated resistance to dapsone after several years of monotherapy, and following subsequent MDT the studies demonstrated the development of resistance to rifampin.
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 - http://www.ncbi.nlm.nih.gov/pubmed/12914130?dopt=Abstract DA - 2003 Mar IS - 1 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -This is the first report of secondary resistance to rifampin following MDT in a patient with prolonged, but irregular treatment. Repeated mouse foot-pad studies demonstrated resistance to dapsone after several years of monotherapy, and following subsequent MDT the studies demonstrated the development of resistance to rifampin.
PY - 2003 SP - 18 EP - 21 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Secondary rifampin resistance following multi-drug therapy--a case report. UR - http://ila.ilsl.br/pdfs/v71n1a04.pdf VL - 71 SN - 0148-916X ER -