TY - JOUR
KW - Biopsy
KW - Cyclooxygenase 2
KW - Humans
KW - Isoenzymes
KW - Leprosy, lepromatous
KW - Leprosy, Tuberculoid
KW - Macrophages
KW - Membrane Proteins
KW - Prostaglandin-Endoperoxide Synthases
AU - Kiszewski A E C
AU - Becerril E
AU - Baquera J
AU - Ruiz-Maldonado R
AU - Hernández Pando R
AB - <p><b>BACKGROUND: </b>Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy.</p><p><b>OBJECTIVES: </b>To compare the COX-2 expression in LL and TL.</p><p><b>METHODS: </b>Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells.</p><p><b>RESULTS: </b>Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0.001 by Student's t-test).</p><p><b>CONCLUSIONS: </b>The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy.</p>
BT - The British journal of dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/12752141?dopt=Abstract
DA - 2003 Apr
DO - 10.1046/j.1365-2133.2003.05179.x
IS - 4
J2 - Br. J. Dermatol.
LA - eng
N2 - <p><b>BACKGROUND: </b>Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy.</p><p><b>OBJECTIVES: </b>To compare the COX-2 expression in LL and TL.</p><p><b>METHODS: </b>Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells.</p><p><b>RESULTS: </b>Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0.001 by Student's t-test).</p><p><b>CONCLUSIONS: </b>The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy.</p>
PY - 2003
SP - 795
EP - 8
T2 - The British journal of dermatology
TI - Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions.
VL - 148
SN - 0007-0963
ER -