BACKGROUND AND OBJECTIVE: Leprosy is a chronic slowly progressive infection caused by Mycobacterium leprae that primarily affects the skin and peripheral nerves. Lepromatous leprosy is characterized by absence of T-cell responses to M. leprae and advanced clinical disease. It is frequently associated with the presence of autoantibodies, which might be related to CD19CD5 and CD19CD5 B lymphocyte percentages. Therefore, the aim of this study was to evaluate the percentages of CD19CD5 and CD19CD5 B cell subsets as well as the total B cells in lepromatous leprosy patients.
MATERIALS AND METHODS: Twenty lepromatous leprosy patients and ten healthy subjects served as control were included in this study. Venous blood samples were analyzed by flow cytometry to determine the B cell subsets and total B cell percentages.
RESULTS: Compared to healthy controls, the percentages of CD19CD5 B cell subset and total B cells were found to be significantly higher in the patient group. While, the percentage of CD19CD5 B cell subset was found to be higher in the patient group than the control without any significantly difference. Regarding the eye affection, the percentage of total B cells was observed to be significantly higher in affected patients compared to the non-affected group.
CONCLUSION: The observed significant increases in CD19CD5 and total B cell percentages in patients with lepromatous leprosy suggests a possible role of these cells in the disorganized protective immune response as well as the development of eye complications in these patients.
BT - Journal of infection and public health C1 -http://www.ncbi.nlm.nih.gov/pubmed/30904499?dopt=Abstract
DO - 10.1016/j.jiph.2019.03.001 J2 - J Infect Public Health LA - eng N2 -BACKGROUND AND OBJECTIVE: Leprosy is a chronic slowly progressive infection caused by Mycobacterium leprae that primarily affects the skin and peripheral nerves. Lepromatous leprosy is characterized by absence of T-cell responses to M. leprae and advanced clinical disease. It is frequently associated with the presence of autoantibodies, which might be related to CD19CD5 and CD19CD5 B lymphocyte percentages. Therefore, the aim of this study was to evaluate the percentages of CD19CD5 and CD19CD5 B cell subsets as well as the total B cells in lepromatous leprosy patients.
MATERIALS AND METHODS: Twenty lepromatous leprosy patients and ten healthy subjects served as control were included in this study. Venous blood samples were analyzed by flow cytometry to determine the B cell subsets and total B cell percentages.
RESULTS: Compared to healthy controls, the percentages of CD19CD5 B cell subset and total B cells were found to be significantly higher in the patient group. While, the percentage of CD19CD5 B cell subset was found to be higher in the patient group than the control without any significantly difference. Regarding the eye affection, the percentage of total B cells was observed to be significantly higher in affected patients compared to the non-affected group.
CONCLUSION: The observed significant increases in CD19CD5 and total B cell percentages in patients with lepromatous leprosy suggests a possible role of these cells in the disorganized protective immune response as well as the development of eye complications in these patients.
PY - 2019 T2 - Journal of infection and public health TI - Increased CD5+ B-cells are associated with autoimmune phenomena in lepromatous leprosy patients. UR - https://www.sciencedirect.com/science/article/pii/S1876034119301108?via%3Dihub SN - 1876-035X ER -