A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented. His clinical features included erythematous, edematous plaques and peripheral neuropathy. Reversal reactions are caused immunologically by enhanced cell-mediated (Th-1) immunity to Mycobacterium leprae, resulting in inflammation of infected tissues, such as skin and nerves. Acute neuritis can lead to permanent nerve damage and necessitate prompt treatment with prednisone and/or clofazamine.
BT - Journal of drugs in dermatology : JDD C1 - http://www.ncbi.nlm.nih.gov/pubmed/12847760?dopt=Abstract DA - 2002 Jul IS - 1 J2 - J Drugs Dermatol LA - eng N2 -A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented. His clinical features included erythematous, edematous plaques and peripheral neuropathy. Reversal reactions are caused immunologically by enhanced cell-mediated (Th-1) immunity to Mycobacterium leprae, resulting in inflammation of infected tissues, such as skin and nerves. Acute neuritis can lead to permanent nerve damage and necessitate prompt treatment with prednisone and/or clofazamine.
PY - 2002 SP - 70 EP - 1 T2 - Journal of drugs in dermatology : JDD TI - Reversal reaction to Hansen's disease. VL - 1 SN - 1545-9616 ER -