TY - JOUR
KW - leprosy
KW - CD4+ RORg-T Th17
KW - CD25+ FOXP3+ Treg
KW - IL17
KW - TGF-β
KW - Reversal reaction
KW - Erythema nodosum leprosum (ENL)
AU - Yuniati R
AU - Riawan W
AU - Widasmara D
AU - Darmaputra I
AU - Arifin S
AB - <p><strong><em>Objective </em></strong>To compare the distribution of CD4+ Th17 and CD25+ FOXP3 T regulatory cell (Treg) between type I reversal reaction (RR) and type II reversal reaction i.e. erythema nodosum leprosum (ENL) patient groups.</p>

<p><em><strong>Methods </strong></em>A total of 50 samples, consisted of 27 samples of reversal reaction (RR) and 23 samples of ENL, were collected. Observation of CD4+ RORg-T Th17 and CD25+ FOXP3 Treg were conducted with immunohistochemistry staining technique using anti FOX-P3 and anti RORg-T. Expression of CD4+ ROR-g Th17 and CD25+ FOXP3 Treg in percentage were analyzed using T-test.</p>

<p><em><strong>Results </strong></em>There is a significant difference in mean CD4+ ROR-g Th17 and IL17 cell distribution for RR patient group (14.96% and 10.72%) compared with ENL (9.12% and 4.28%). No significant difference were found between mean CD25+ FOXP3 Treg and TGF-β cell distribution in RR patient group (6.12% and 5.44%) compared with ENL group (6.16% and 5.96%).</p>

<p><em><strong>Conclusion </strong></em>There is a significant increment od CD+RORg-T Th17 and IL17 in RR patients group compared with ENL patients group. however, the distribution of CD25+ FOXP3+ Treg and TGF beta in RR has no significant difference compared with ENL.</p>

BT - Journal of Pakistan Association of Dermatologists : JPAD
IS - 2
LA - eng
N2 - <p><strong><em>Objective </em></strong>To compare the distribution of CD4+ Th17 and CD25+ FOXP3 T regulatory cell (Treg) between type I reversal reaction (RR) and type II reversal reaction i.e. erythema nodosum leprosum (ENL) patient groups.</p>

<p><em><strong>Methods </strong></em>A total of 50 samples, consisted of 27 samples of reversal reaction (RR) and 23 samples of ENL, were collected. Observation of CD4+ RORg-T Th17 and CD25+ FOXP3 Treg were conducted with immunohistochemistry staining technique using anti FOX-P3 and anti RORg-T. Expression of CD4+ ROR-g Th17 and CD25+ FOXP3 Treg in percentage were analyzed using T-test.</p>

<p><em><strong>Results </strong></em>There is a significant difference in mean CD4+ ROR-g Th17 and IL17 cell distribution for RR patient group (14.96% and 10.72%) compared with ENL (9.12% and 4.28%). No significant difference were found between mean CD25+ FOXP3 Treg and TGF-β cell distribution in RR patient group (6.12% and 5.44%) compared with ENL group (6.16% and 5.96%).</p>

<p><em><strong>Conclusion </strong></em>There is a significant increment od CD+RORg-T Th17 and IL17 in RR patients group compared with ENL patients group. however, the distribution of CD25+ FOXP3+ Treg and TGF beta in RR has no significant difference compared with ENL.</p>

PY - 2018
SP - 123
EP - 128
ST - JPAD
T2 - Journal of Pakistan Association of Dermatologists : JPAD
TI - Distribution of CD4+RORg-T Th17 and CD25+ FOXP3+ Treg in leprosy patients with reversal reaction.
UR - http://jpad.com.pk/index.php/jpad/article/viewFile/1102/1099
VL - 28
ER -