TY - JOUR KW - Chromosomes, Human, Pair 6 KW - Female KW - Genetic Linkage KW - Genetic Predisposition to Disease KW - genotype KW - HLA Antigens KW - Humans KW - leprosy KW - Male KW - Pedigree KW - Phenotype KW - Tumor Necrosis Factor-alpha AU - Mira M T AU - Alcaïs A AU - Pietrantonio T AU - Thuc N V AU - Phuong M C AU - Abel L AU - Schurr E AB -

Each year an estimated 600000 new leprosy cases are diagnosed worldwide. The spectrum of the disease varies widely from limited tuberculoid forms to extensive lepromatous forms. A measure of the risk to develop lepromatous forms of leprosy is provided by the extent of skin reactivity to lepromin (Mitsuda reaction). To address a postulated oligogenic control of leprosy pathogenesis, we investigated in the present study linkage of leprosy susceptibility, leprosy clinical subtypes, and extent of the Mitsuda reaction to six chromosomal regions carrying known or suspected leprosy susceptibility loci. The only significant result obtained was linkage of leprosy clinical subtype to the HLA/TNF region on human chromosome 6p21 (P(corrected)=0.00126). In addition, we established that within the same family different HLA/TNF haplotypes segregate into patients with different leprosy subtypes directly demonstrating the importance of this genome region for the control of clinical leprosy presentation.

BT - Genes and immunity C1 - http://www.ncbi.nlm.nih.gov/pubmed/12595904?dopt=Abstract CN - MIRA 2003 DA - 2003 Jan DO - 10.1038/sj.gene.6363911 IS - 1 J2 - Genes Immun. LA - eng N2 -

Each year an estimated 600000 new leprosy cases are diagnosed worldwide. The spectrum of the disease varies widely from limited tuberculoid forms to extensive lepromatous forms. A measure of the risk to develop lepromatous forms of leprosy is provided by the extent of skin reactivity to lepromin (Mitsuda reaction). To address a postulated oligogenic control of leprosy pathogenesis, we investigated in the present study linkage of leprosy susceptibility, leprosy clinical subtypes, and extent of the Mitsuda reaction to six chromosomal regions carrying known or suspected leprosy susceptibility loci. The only significant result obtained was linkage of leprosy clinical subtype to the HLA/TNF region on human chromosome 6p21 (P(corrected)=0.00126). In addition, we established that within the same family different HLA/TNF haplotypes segregate into patients with different leprosy subtypes directly demonstrating the importance of this genome region for the control of clinical leprosy presentation.

PY - 2003 SP - 67 EP - 73 T2 - Genes and immunity TI - Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes. UR - http://www.nature.com/gene/journal/v4/n1/pdf/6363911a.pdf VL - 4 SN - 1466-4879 ER -