TY - JOUR
KW - Adolescent
KW - Child
KW - Child, Preschool
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Immunity, Cellular
KW - leprosy
KW - Lymphocyte Activation
KW - Male
KW - New Guinea
KW - Skin Tests
AU - Price M A
AU - Anders E M
AU - Anders R F
AU - Russel D A
AU - Dennis E S
AB - <p>The cell-mediated immune status of 20 apparently healthy children from families with a history of leprosy has been studied. They have been compared with 20 age- and sex-matched controls from families with no history of leprosy. Lymphocyte transformation tests using PHA, PPD and lepromin and skin tests to lepromin, PPD and candida were carried out. No evidence of a depression of cell-mediated immunity in the children from families with leprosy was obtained. The only two children giving a negative Mitsuda lepromin skin test both subsequently developed leprosy in the succeeding 16 months. One was classified histologically as indefinite lepromatous and the other as borderline lepromatous. This emphasizes the practical significance of a negative lepromin skin test in an endemic leprosy area as a prognosis of clinical lepromatous leprosy.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1241686?dopt=Abstract
DA - 1975 Oct-Dec
IS - 4
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>The cell-mediated immune status of 20 apparently healthy children from families with a history of leprosy has been studied. They have been compared with 20 age- and sex-matched controls from families with no history of leprosy. Lymphocyte transformation tests using PHA, PPD and lepromin and skin tests to lepromin, PPD and candida were carried out. No evidence of a depression of cell-mediated immunity in the children from families with leprosy was obtained. The only two children giving a negative Mitsuda lepromin skin test both subsequently developed leprosy in the succeeding 16 months. One was classified histologically as indefinite lepromatous and the other as borderline lepromatous. This emphasizes the practical significance of a negative lepromin skin test in an endemic leprosy area as a prognosis of clinical lepromatous leprosy.</p>
PY - 1975
SP - 307
EP - 13
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - Cell-mediated immunologic status of healthy members of families with a history of leprosy.
VL - 43
SN - 0148-916X
ER -