Dapsone has been part of the World Health Organization multidrug therapy for the treatment of leprosy. While it has been efficacious in the management of leprosy, there are many patients who develop adverse drug reactions to the drug including life-threatening reactions such as dapsone hypersensitivity syndrome (DHS). We report a case of a patient who was prescribed dapsone as part of multidrug therapy for leprosy following which she developed DHS. Her condition worsened after tapering the oral steroids given to manage the DHS, and she was detected to have hypothyroidism. She developed diabetes mellitus and succumbed to septic shock.
BT - Indian journal of pharmacology C1 -http://www.ncbi.nlm.nih.gov/pubmed/29515281?dopt=Abstract
DO - 10.4103/ijp.IJP_764_16 IS - 5 J2 - Indian J Pharmacol LA - eng N2 -Dapsone has been part of the World Health Organization multidrug therapy for the treatment of leprosy. While it has been efficacious in the management of leprosy, there are many patients who develop adverse drug reactions to the drug including life-threatening reactions such as dapsone hypersensitivity syndrome (DHS). We report a case of a patient who was prescribed dapsone as part of multidrug therapy for leprosy following which she developed DHS. Her condition worsened after tapering the oral steroids given to manage the DHS, and she was detected to have hypothyroidism. She developed diabetes mellitus and succumbed to septic shock.
PY - 2017 SP - 396 EP - 398 T2 - Indian journal of pharmacology TI - Fatal dapsone hypersensitivity syndrome with hypothyroidism and steroid-induced diabetes mellitus. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830851/ VL - 49 SN - 1998-3751 ER -