TY - JOUR
KW - Adolescent
KW - Adult
KW - Antimalarials
KW - Blood Cell Count
KW - Case-Control Studies
KW - Dapsone
KW - Female
KW - Hemoglobins
KW - Humans
KW - leprosy
KW - Male
KW - Nigeria
KW - Reticulocyte Count
AU - Halim N K D
AU - Ogbeide E
AB - <p><b>OBJECTIVE: </b>To evaluate the haemoglobin concentration (Hb); total white blood cell count (WBC), differential WBC count; platelet count and reticulocyte count in leprosy patients already treated with dapsone.</p><p><b>DESIGN: </b>A case-control study.</p><p><b>SETTING: </b>Specialist Hospital Ossiomo, which is a Leprosarium and Haematology laboratory, University of Benin Teaching Hospital (UBTH), Nigeria.</p><p><b>SUBJECTS: </b>Seventy six leprosy patients (forty males and thirty six females) age range 13-40 years on single dose dapsone.</p><p><b>RESULTS: </b>The haemoglobin concentration showed a marked decrease while the reticulocyte count was markedly elevated which was suggestive of haemolytic anaemia. There was also lymphocytosis in patients during pre and post dapsone therapy.</p><p><b>CONCLUSION: </b>Leprosy patients on a dosage of 100 mg dapsone, are prone to haemolytic anaemia. Leprosy patients should routinely have their Hb, WBC, platelet count and reticulocyte count determined, while on dapsone therapy in order to ascertain the presence of haemolysis.</p>
BT - East African medical journal
C1 - http://www.ncbi.nlm.nih.gov/pubmed/12380888?dopt=Abstract
DA - 2002 Feb
DO - 10.4314/eamj.v79i2.8912
IS - 2
J2 - East Afr Med J
LA - eng
N2 - <p><b>OBJECTIVE: </b>To evaluate the haemoglobin concentration (Hb); total white blood cell count (WBC), differential WBC count; platelet count and reticulocyte count in leprosy patients already treated with dapsone.</p><p><b>DESIGN: </b>A case-control study.</p><p><b>SETTING: </b>Specialist Hospital Ossiomo, which is a Leprosarium and Haematology laboratory, University of Benin Teaching Hospital (UBTH), Nigeria.</p><p><b>SUBJECTS: </b>Seventy six leprosy patients (forty males and thirty six females) age range 13-40 years on single dose dapsone.</p><p><b>RESULTS: </b>The haemoglobin concentration showed a marked decrease while the reticulocyte count was markedly elevated which was suggestive of haemolytic anaemia. There was also lymphocytosis in patients during pre and post dapsone therapy.</p><p><b>CONCLUSION: </b>Leprosy patients on a dosage of 100 mg dapsone, are prone to haemolytic anaemia. Leprosy patients should routinely have their Hb, WBC, platelet count and reticulocyte count determined, while on dapsone therapy in order to ascertain the presence of haemolysis.</p>
PY - 2002
SP - 100
EP - 2
T2 - East African medical journal
TI - Haematological alterations in leprosy patients treated with dapsone.
VL - 79
SN - 0012-835X
ER -