Between 1989 and 1993, 136 multibacillary leprosy patients received a 6-week treatment regimen consisting of daily rifampicin 600 mg, ofloxacin 400 mg, clofazimine 100 mg and a weekly dose of 100 mg minocycline. A previous analysis after a mean follow-up of 4-7 years revealed a relapse rate of 2%, involving six late (after more than 5 years of follow-up) relapses. During the following years, 12 more relapses appeared during years 8-9 of follow-up. A mean follow-up period of 5 years is insufficient to evaluate treatment regimens in multibacillary leprosy. The present regimen cannot be recommended.
BT - Leprosy review C1 - http://www.ncbi.nlm.nih.gov/pubmed/12449889?dopt=Abstract CN - Infolep Library - available DA - 2002 Sep DO - 10.47276/lr.73.3.245 IS - 3 J2 - Lepr Rev LA - eng N2 -Between 1989 and 1993, 136 multibacillary leprosy patients received a 6-week treatment regimen consisting of daily rifampicin 600 mg, ofloxacin 400 mg, clofazimine 100 mg and a weekly dose of 100 mg minocycline. A previous analysis after a mean follow-up of 4-7 years revealed a relapse rate of 2%, involving six late (after more than 5 years of follow-up) relapses. During the following years, 12 more relapses appeared during years 8-9 of follow-up. A mean follow-up period of 5 years is insufficient to evaluate treatment regimens in multibacillary leprosy. The present regimen cannot be recommended.
PY - 2002 SP - 245 EP - 7 T2 - Leprosy review TI - Relapse rates and a 10-year follow-up of a 6-week quadruple drug regimen for multibacillary leprosy. UR - https://leprosyreview.org/article/73/3/24-5247 VL - 73 SN - 0305-7518 ER -