Leprosy is a chronic disease, caused by M. leprae where involvement and damage of peripheral nerves is a typical and unique feature. The presence of M. leprae has been shown in Schwan cells (SCs) of unmyelinated nerve fibers, macrophages, and Endothelial cell (EC). The presence of M. leprae in endothelial cells suggested that SCs are not the only target cells for M. leprae infection, but the organisms are also frequently seen in the EC of the endoneurial blood vessels (EBV). In the light of increasing resistance and complication of leprosy reaction, to dapsone (DDS) and rifampicin, Clofzamin (CLF) has been included as an essential component of multidrug therapy (MDT) in standard W.H.O. regimen. Interesting observations has been recorded by various investigators in LL patients, receiving continuous MDT for several years; viable bacilli were found in peripheral nerves whereas they had disappeared from the skin. In this article, we review the different recent pathway in understanding the possible and most frequent route of entry M.leprae into the nerve.
BT - International journal of research studies in medical and health sciences IS - 7 LA - eng N2 -Leprosy is a chronic disease, caused by M. leprae where involvement and damage of peripheral nerves is a typical and unique feature. The presence of M. leprae has been shown in Schwan cells (SCs) of unmyelinated nerve fibers, macrophages, and Endothelial cell (EC). The presence of M. leprae in endothelial cells suggested that SCs are not the only target cells for M. leprae infection, but the organisms are also frequently seen in the EC of the endoneurial blood vessels (EBV). In the light of increasing resistance and complication of leprosy reaction, to dapsone (DDS) and rifampicin, Clofzamin (CLF) has been included as an essential component of multidrug therapy (MDT) in standard W.H.O. regimen. Interesting observations has been recorded by various investigators in LL patients, receiving continuous MDT for several years; viable bacilli were found in peripheral nerves whereas they had disappeared from the skin. In this article, we review the different recent pathway in understanding the possible and most frequent route of entry M.leprae into the nerve.
PY - 2017 SP - 8 EP - 18 T2 - International journal of research studies in medical and health sciences TI - Emerging concept on peripheral nerve damage in leprosy UR - http://www.ijrsmhs.com/pdf/v2-i7/2.pdf VL - 2 ER -