Two recent articles advance our understanding of mycobacterial pathogenesis, revealing key roles for bacterially derived phenolic glycolipids (PGLs). In leprosy, Mycobacterium leprae PGL-1 uniquely subverts local macrophages to produce neurotoxic nitric oxide (NO), leading to nerve demyelination. In a related model, Mycobacterium marinum PGL stimulates the recruitment of growth-conducive monocytes to sites of initial infection as an early immune evasion strategy.
BT - Trends in molecular medicine C1 -http://www.ncbi.nlm.nih.gov/pubmed/28969977?dopt=Abstract
DO - 10.1016/j.molmed.2017.09.003 J2 - Trends Mol Med LA - eng N2 -Two recent articles advance our understanding of mycobacterial pathogenesis, revealing key roles for bacterially derived phenolic glycolipids (PGLs). In leprosy, Mycobacterium leprae PGL-1 uniquely subverts local macrophages to produce neurotoxic nitric oxide (NO), leading to nerve demyelination. In a related model, Mycobacterium marinum PGL stimulates the recruitment of growth-conducive monocytes to sites of initial infection as an early immune evasion strategy.
PY - 2017 T2 - Trends in molecular medicine TI - Partners in Crime: Phenolic Glycolipids and Macrophages. SN - 1471-499X ER -