A 24 years old male presented with multiple, shiny, infiltrated papules, plaques with central crusting and ulceration without any systemic features. Histopathological examination of the skin nodule showed perivascular and perineural collection of foamy histiocytes, few neutrophils and lymphocytes. Superficially below the epidermis there was localised area of necrosis with macrophages and infiltration of neutrophils. Fite stain was positive for AFB thus proving a diagnosis of lepromatous leprosy with exacerbation reaction. In rare instances in lepromatous leprosy exacerbation reaction occurs locally in hyperactive granulomas which may mimic erythema nodosum leprosum clinically.
BT - Indian journal of leprosy J2 - Indian J Lepr LA - eng N2 -A 24 years old male presented with multiple, shiny, infiltrated papules, plaques with central crusting and ulceration without any systemic features. Histopathological examination of the skin nodule showed perivascular and perineural collection of foamy histiocytes, few neutrophils and lymphocytes. Superficially below the epidermis there was localised area of necrosis with macrophages and infiltration of neutrophils. Fite stain was positive for AFB thus proving a diagnosis of lepromatous leprosy with exacerbation reaction. In rare instances in lepromatous leprosy exacerbation reaction occurs locally in hyperactive granulomas which may mimic erythema nodosum leprosum clinically.
PY - 2016 SP - 245 EP - 249 T2 - Indian journal of leprosy TI - Exacerbation Reaction in a Case of Lepromatous Leprosy: An Intrigue! UR - http://www.ijl.org.in/2016/8%20R%20Misri%20et%20al(245-250).pdf VL - 88 ER -