Leprosy is an infectious disease, caused by Mycobacterium leprae, which encompasses a wide clinical spectrum based on the host immune response. At one end of the spectrum, tuberculoid leprosy (T-lep) patients manifest a strong cell-mediated immune response that restricts the growth of the pathogen, while at the other extreme, lepromatous leprosy (L-lep) patients have a weak cell-mediated immune response associated with dissemination of the infection. This spectrum also correlates with the levels of apoptosis in lesions, or evidence of programmed cell death via the activation of caspases and proteases.
BT - Journal of the American Academy of Dermatology DO - 10.1016/j.jaad.2017.04.778 IS - 6 J2 - J. Am. Acad. Dermatol. LA - eng N2 -Leprosy is an infectious disease, caused by Mycobacterium leprae, which encompasses a wide clinical spectrum based on the host immune response. At one end of the spectrum, tuberculoid leprosy (T-lep) patients manifest a strong cell-mediated immune response that restricts the growth of the pathogen, while at the other extreme, lepromatous leprosy (L-lep) patients have a weak cell-mediated immune response associated with dissemination of the infection. This spectrum also correlates with the levels of apoptosis in lesions, or evidence of programmed cell death via the activation of caspases and proteases.
PY - 2017 EP - AB199 T2 - Journal of the American Academy of Dermatology TI - PLAU and SerpinB2 role in apoptosis in leprosy VL - 76 SN - 01909622 ER -