Background: Peripheral neuropathy is a central feature of leprosy. Intraneural inflammation caused by M. leprae is the morphological hallmark of this disease, FNAC of sensory cutaneous nerve has proved to be a valuable diagnostic tool.
Materials and methods: The data of patients with sensory cutaneous nerve involvement were retrieved from our record for the period from Nov 2014 to Sept 2015. The hematoxylin and eosin (H and E)- and May-Grünwald-Giemsa (MGG)-stained slides were screened for Schwann cells, granuloma, and necrosis. Modifi ed Ziehl-Neelsen (ZN)-stained smears were searched for single lepra bacilli and globi.
Results: Twenty-five sensory cutaneous nerves were aspirated. Out of which 19 yielded diagnostic aspirate. Five cytologic pictures were seen - epithelioid cell granulomas (6), epithelioidcell granulomas with necrosis (3);necrosis + lepra bacilli (4); only lepra bacilli (2); and lymphocyte & macrophage infiltrate (4).Following the Ridley-Jopling classification, in our study there were 9 cases of TT, 4 of BT-TT, 1 of BB, 2 of BL, and 3 of LL.
Conclusion: FNAC of sensory cutaneous nerve is useful in diagnosis and classification of leprosy on the R-J scale.
BT - Annals of pathology and laboratory medicine IS - 2 LA - eng N2 -Background: Peripheral neuropathy is a central feature of leprosy. Intraneural inflammation caused by M. leprae is the morphological hallmark of this disease, FNAC of sensory cutaneous nerve has proved to be a valuable diagnostic tool.
Materials and methods: The data of patients with sensory cutaneous nerve involvement were retrieved from our record for the period from Nov 2014 to Sept 2015. The hematoxylin and eosin (H and E)- and May-Grünwald-Giemsa (MGG)-stained slides were screened for Schwann cells, granuloma, and necrosis. Modifi ed Ziehl-Neelsen (ZN)-stained smears were searched for single lepra bacilli and globi.
Results: Twenty-five sensory cutaneous nerves were aspirated. Out of which 19 yielded diagnostic aspirate. Five cytologic pictures were seen - epithelioid cell granulomas (6), epithelioidcell granulomas with necrosis (3);necrosis + lepra bacilli (4); only lepra bacilli (2); and lymphocyte & macrophage infiltrate (4).Following the Ridley-Jopling classification, in our study there were 9 cases of TT, 4 of BT-TT, 1 of BB, 2 of BL, and 3 of LL.
Conclusion: FNAC of sensory cutaneous nerve is useful in diagnosis and classification of leprosy on the R-J scale.
PY - 2017 SP - 157 EP - 162 ST - APALM T2 - Annals of pathology and laboratory medicine TI - Diagnostic utility of fine needle aspiration cytology of sensory cutaneous nerve in leprosy UR - http://www.pacificejournals.com/journal/index.php/apalm/article/view/1178/pdf_345 VL - 4 ER -