The complement system is a part of the innate immunity, and plays an important role in host immunity and inflammation. We previously identified the terminal membrane attack complex (MAC) of the complement system as a key determinant of neurodegeneration and demonstrated that its inhibition is neuroprotective. Besides being part of a mechanism of defence to invading pathogens, MAC has the capacity to cause damage to self-cells and is consequently implicated in many diseases.
BT - Faculty of Medicine (AMC-UvA) CN - BAHIAELIDRISSI2017 CY - Amsterdam LA - eng N2 -The complement system is a part of the innate immunity, and plays an important role in host immunity and inflammation. We previously identified the terminal membrane attack complex (MAC) of the complement system as a key determinant of neurodegeneration and demonstrated that its inhibition is neuroprotective. Besides being part of a mechanism of defence to invading pathogens, MAC has the capacity to cause damage to self-cells and is consequently implicated in many diseases.
PB - University of Amsterdam PP - Amsterdam PY - 2017 EP - 275 p. T2 - Faculty of Medicine (AMC-UvA) TI - Complement in neuroinflammation : Studies in leprosy and Amyotrophic Lateral Sclerosis UR - http://hdl.handle.net/11245.1/6455df2c-f9a6-403a-8061-7260d7446e3b ER -