Leprosy is a chronic infectious granulomatous disease caused by the obligate intracellular bacteria Mycobacterium leprae. M. leprae causes symptoms in the skin, peripheral nerves, and other tissues. Type 1 (reversal reaction) and type 2 (erythema nodosum leprosum) lepra reactions are the main mechanisms of skin lesions, nerve damage, and other types of tissue damages. Susceptibility to mycobacterial infection and the clinical presentations of the disease are associated with aberrant host immune response, which forms the spectrum and pathologic manifestations of the disease.
BT - Current Tropical Medicine Reports DO - 10.1007/s40475-016-0094-y J2 - Curr Trop Med Rep LA - eng N2 -Leprosy is a chronic infectious granulomatous disease caused by the obligate intracellular bacteria Mycobacterium leprae. M. leprae causes symptoms in the skin, peripheral nerves, and other tissues. Type 1 (reversal reaction) and type 2 (erythema nodosum leprosum) lepra reactions are the main mechanisms of skin lesions, nerve damage, and other types of tissue damages. Susceptibility to mycobacterial infection and the clinical presentations of the disease are associated with aberrant host immune response, which forms the spectrum and pathologic manifestations of the disease.
PY - 2016 T2 - Current Tropical Medicine Reports TI - Molecular Pathogenesis of Leprosy UR - http://link.springer.com/article/10.1007/s40475-016-0094-y ER -