TY - JOUR KW - Base Sequence KW - DNA, Bacterial KW - Female KW - genotype KW - Humans KW - Incidence KW - Korea KW - leprosy KW - Male KW - Molecular Sequence Data KW - Mycobacterium leprae KW - polymerase chain reaction KW - Probability KW - Sensitivity and Specificity KW - Tandem Repeat Sequences AU - Chae G T AU - Lee S B AU - Kang T J AU - Shin H K AU - Kim J P AU - Ko Y H AU - Kim S H AU - Kim N H AB -

Although there is no genetic diversity in isolates of Mycobacterium leprae, the variance of tandem repeats in the rpoT gene was recently demonstrated. We have typed clinical isolates of M. leprae in Korea using difference of the tandem repeats in the rpoT gene. Among 69 patients, 65 Korean isolates (94.2%) demonstrated four copies of the 6 bp tandem repeat (GACATC) in the rpoT gene, and incidences of three copies were found in only two Koreans and two foreigners (2.9%, respectively).

BT - Leprosy review C1 - http://www.ncbi.nlm.nih.gov/pubmed/11969125?dopt=Abstract CN - Infolep Library - available DA - 2002 Mar IS - 1 J2 - Lepr Rev LA - eng N2 -

Although there is no genetic diversity in isolates of Mycobacterium leprae, the variance of tandem repeats in the rpoT gene was recently demonstrated. We have typed clinical isolates of M. leprae in Korea using difference of the tandem repeats in the rpoT gene. Among 69 patients, 65 Korean isolates (94.2%) demonstrated four copies of the 6 bp tandem repeat (GACATC) in the rpoT gene, and incidences of three copies were found in only two Koreans and two foreigners (2.9%, respectively).

PY - 2002 SP - 41 EP - 6 T2 - Leprosy review TI - Typing of clinical isolates of Mycobacterium leprae and their distribution in Korea. UR - https://leprosyreview.org/article/73/1/00-0006 VL - 73 SN - 0305-7518 ER -