TY - JOUR
KW - Acyltransferases
KW - Animals
KW - Antigens, Bacterial
KW - Bacterial Proteins
KW - Bacterial Vaccines
KW - Foot
KW - leprosy
KW - Mice
KW - Mycobacterium leprae
KW - Vaccination
KW - Vaccines, DNA
KW - Virulence
AU - Roche P W
AU - Neupane K D
AU - Failbus S S
AU - Kamath A
AU - Britton W J
AB - <p>A DNA vaccine composed of the gene for the common mycobacterial secreted protein antigen 85B was demonstrated to protect the mouse foot pad against infection with Mycobacterium leprae. The protective effect was demonstrated by a 61%-88% reduction in the bacterial number, a protective effect less than that of BCG. The same DNA vaccine has been shown to protect mice against M. tuberculosis infection, and the importance of testing other candidate tuberculosis vaccines for their potential to protect against leprosy is discussed.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11757171?dopt=Abstract
DA - 2001 Jun
IS - 2
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>A DNA vaccine composed of the gene for the common mycobacterial secreted protein antigen 85B was demonstrated to protect the mouse foot pad against infection with Mycobacterium leprae. The protective effect was demonstrated by a 61%-88% reduction in the bacterial number, a protective effect less than that of BCG. The same DNA vaccine has been shown to protect mice against M. tuberculosis infection, and the importance of testing other candidate tuberculosis vaccines for their potential to protect against leprosy is discussed.</p>
PY - 2001
SP - 93
EP - 8
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - Vaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae.
UR - http://ila.ilsl.br/pdfs/v69n2a01.pdf
VL - 69
SN - 0148-916X
ER -