TY - JOUR
KW - Age of Onset
KW - Aged
KW - Alleles
KW - Case-Control Studies
KW - China
KW - Ethnic Groups
KW - Female
KW - Gene Frequency
KW - Genetic Association Studies
KW - HLA-DR Antigens
KW - HLA-DRB1 Chains
KW - Humans
KW - leprosy
KW - Leprosy, Multibacillary
KW - Leprosy, Paucibacillary
KW - Male
KW - Young Adult
AU - Zhang F
AU - Liu H
AU - Chen S
AU - Wang C
AU - Zhu C
AU - Zhang L
AU - Chu T
AU - Liu D
AU - Yan X
AU - Liu J
AB - <p><b>BACKGROUND: </b>Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to Mycobacterium leprae. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population.</p><p><b>METHODS: </b>The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals.</p><p><b>RESULTS: </b>The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease.</p><p><b>CONCLUSION: </b>HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.</p>
BT - BMC medical genetics
C1 - http://www.ncbi.nlm.nih.gov/pubmed/20003324?dopt=Abstract
DA - 2009 Dec 11
DO - 10.1186/1471-2350-10-133
J2 - BMC Med. Genet.
LA - eng
N2 - <p><b>BACKGROUND: </b>Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to Mycobacterium leprae. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population.</p><p><b>METHODS: </b>The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals.</p><p><b>RESULTS: </b>The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease.</p><p><b>CONCLUSION: </b>HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.</p>
PY - 2009
EP - 133
T2 - BMC medical genetics
TI - Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population.
VL - 10
SN - 1471-2350
ER -