TY - JOUR
KW - Adult
KW - African Continental Ancestry Group
KW - Case-Control Studies
KW - Cation Transport Proteins
KW - Female
KW - Genetic Predisposition to Disease
KW - genotype
KW - Humans
KW - leprosy
KW - Male
KW - Mali
KW - Middle Aged
KW - Polymorphism, Genetic
AU - Meisner S J
AU - Mucklow S
AU - Warner G
AU - Sow S O
AU - Lienhardt C
AU - Hill A V
AB - <p>Twin and family studies indicate that host genetic factors influence susceptibility to leprosy and, possibly, leprosy type. Murine studies have suggested a role for the natural resistance-associated macrophage protein 1 (Nramp1) gene, which can influence cellular immune responses to intracellular pathogens. We evaluated a variation in the human homolog, NRAMP1, recently associated with tuberculosis susceptibility in West Africa. A total of 273 patients with leprosy and 201 controls from Mali were genotyped for NRAMP1 polymorphisms previously associated with tuberculosis. No association was found with leprosy per se (P = 0.83), but the NRAMP1 3'-untranslated region 4-bp insertion/deletion polymorphism was associated with leprosy type (P = 0.007). Heterozygotes were more frequent among multibacillary than paucibacillary leprosy cases. Thus, variation in or near the NRAMP1 gene may exert an influence on the clinical presentation of leprosy, possibly by influencing cellular immune response type.</p>
BT - The American journal of tropical medicine and hygiene
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11791966?dopt=Abstract
DA - 2001 Dec
DO - 10.4269/ajtmh.2001.65.733
IS - 6
J2 - Am. J. Trop. Med. Hyg.
LA - eng
N2 - <p>Twin and family studies indicate that host genetic factors influence susceptibility to leprosy and, possibly, leprosy type. Murine studies have suggested a role for the natural resistance-associated macrophage protein 1 (Nramp1) gene, which can influence cellular immune responses to intracellular pathogens. We evaluated a variation in the human homolog, NRAMP1, recently associated with tuberculosis susceptibility in West Africa. A total of 273 patients with leprosy and 201 controls from Mali were genotyped for NRAMP1 polymorphisms previously associated with tuberculosis. No association was found with leprosy per se (P = 0.83), but the NRAMP1 3'-untranslated region 4-bp insertion/deletion polymorphism was associated with leprosy type (P = 0.007). Heterozygotes were more frequent among multibacillary than paucibacillary leprosy cases. Thus, variation in or near the NRAMP1 gene may exert an influence on the clinical presentation of leprosy, possibly by influencing cellular immune response type.</p>
PY - 2001
SP - 733
EP - 5
T2 - The American journal of tropical medicine and hygiene
TI - Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans.
VL - 65
SN - 0002-9637
ER -