TY - JOUR
KW - Amino Acid Sequence
KW - Animals
KW - Antibody Specificity
KW - Antigens, Bacterial
KW - Bacterial Proteins
KW - Cloning, Molecular
KW - Epitopes, B-Lymphocyte
KW - Epitopes, T-Lymphocyte
KW - leprosy
KW - Mice
KW - Mice, Inbred BALB C
KW - Molecular Sequence Data
KW - Mycobacterium leprae
KW - Mycobacterium tuberculosis
KW - Recombinant Fusion Proteins
KW - Sequence Analysis, Protein
KW - Sequence Homology, Amino Acid
KW - Subcellular Fractions
AU - Spencer JS
AU - Marques MA
AU - Lima MC B S
AU - Junqueira-Kipnis AP
AU - Gregory B
AU - Truman RW
AU - Brennan PJ
AB - <p>The sequence of the Mycobacterium leprae homologue of ESAT-6 shows only 36% amino acid correspondence to that from Mycobacterium tuberculosis. Anti-M. leprae ESAT-6 polyclonal and monoclonal antibodies and T-cell hybridomas reacted only with the homologous protein and allowed identification of the B- and T-cell epitopes. The protein is expressed in M. leprae and appears in the cell wall fraction. Thus, M. leprae ESAT-6 shows promise as a specific diagnostic agent for leprosy.</p>
BT - Infection and immunity
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11796642?dopt=Abstract
DA - 2002 Feb
DO - 10.1128/iai.70.2.1010-1013.2002
IS - 2
J2 - Infect. Immun.
LA - eng
N2 - <p>The sequence of the Mycobacterium leprae homologue of ESAT-6 shows only 36% amino acid correspondence to that from Mycobacterium tuberculosis. Anti-M. leprae ESAT-6 polyclonal and monoclonal antibodies and T-cell hybridomas reacted only with the homologous protein and allowed identification of the B- and T-cell epitopes. The protein is expressed in M. leprae and appears in the cell wall fraction. Thus, M. leprae ESAT-6 shows promise as a specific diagnostic agent for leprosy.</p>
PY - 2002
SP - 1010
EP - 3
T2 - Infection and immunity
TI - Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127711/pdf/1114.pdf
VL - 70
SN - 0019-9567
ER -