The obligate intracellularism of Mycobacterium leprae may be attributable to the effects of mutations in major metabolic areas due to a genome capable of encoding only about 1600 proteins. Yet cell wall biosynthesis capability remains relatively intact and comparisons with the genome of Mycobacterium tuberculosis provide insights into the genetic basis of a minimal mycobacterial cell wall.
BT - Leprosy review C1 - http://www.ncbi.nlm.nih.gov/pubmed/11826478?dopt=Abstract CN - BRENNAN 2001 DA - 2001 Dec DO - 10.5935/0305-7518.20010050 IS - 4 J2 - Lepr Rev LA - eng N2 -The obligate intracellularism of Mycobacterium leprae may be attributable to the effects of mutations in major metabolic areas due to a genome capable of encoding only about 1600 proteins. Yet cell wall biosynthesis capability remains relatively intact and comparisons with the genome of Mycobacterium tuberculosis provide insights into the genetic basis of a minimal mycobacterial cell wall.
PY - 2001 SP - 415 EP - 28 T2 - Leprosy review TI - Genomic evidence for the retention of the essential mycobacterial cell wall in the otherwise defective Mycobacterium leprae. UR - http://leprev.ilsl.br/pdfs/2001/v72n4/pdf/v72n4a05.pdf VL - 72 SN - 0305-7518 ER -