We studied the role of Vitamin D and its receptor (VDR) in leprosy disease progression. Majority of the individuals from Kolkata, India with type-I or type-II reaction have low levels of Vitamin D3 in serum. Interestingly, individuals with type II reaction associated with neuritis/ENL have very low VDR mRNA expression levels ranging from 5% to 10% only to that of the healthy control samples and this patients also have high bacilli index ranging from 3+ to 5+. This is the first report implicating that VDR expression levels may determine the complexity and severity of leprosy disease progression.
BT - New Microbes and New Infections LA - eng N2 -We studied the role of Vitamin D and its receptor (VDR) in leprosy disease progression. Majority of the individuals from Kolkata, India with type-I or type-II reaction have low levels of Vitamin D3 in serum. Interestingly, individuals with type II reaction associated with neuritis/ENL have very low VDR mRNA expression levels ranging from 5% to 10% only to that of the healthy control samples and this patients also have high bacilli index ranging from 3+ to 5+. This is the first report implicating that VDR expression levels may determine the complexity and severity of leprosy disease progression.
PB - Elsevier PY - 2015 T2 - New Microbes and New Infections TI - Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients UR - http://ac.els-cdn.com/S2052297515000311/1-s2.0-S2052297515000311-main.pdf?_tid=d70be25a-e81b-11e4-a261-00000aab0f6b&acdnat=1429616879_d1ca66ece5eccc3cd56a7be75dbd5429 ER -