TY - JOUR
KW - Sweet Syndrome
KW - Reactions
KW - Pathogenesis
KW - Mimicry
KW - leprosy
KW - Erythema Nodosum
AU - Mahajan V
AU - Abhinav C
AU - Mehta K
AU - Chauhan S
AB - <div dir="ltr">Erythema nodosum leprosum (ENL) lesions may uncommonly develop ulceration, necrosis, pustulation or bullae. This 60year-old female was hospitalised with previously undiagnosed multibacillary (BL) leprosy and Sweet’s syndrome-like ENL, a presentation that is rarely reported. In addition to skin lesions simulating Sweet’s syndrome, she had anaemia, elevated ESR, and a peripheral leucocytosis with neutrophilia, the laboratory features of Sweet’s syndrome. The final diagnosis was made from chronic iridocyclitis, presence of lepra bacilli in slit-skin smears, and histology. The pathogenesis of Sweet’s-like ENL remains conjectural. In Sweet’s syndrome a complex interplay of various cytokines leading to an abundance of pro-inflammatory cytokines in the target tissues has been postulated to initiate an abnormal tissue response to certain antigens; such findings may eventually explain these uncommon lepra reactions as well.</div>

BT - Leprosy review
C1 - <p>http://www.ncbi.nlm.nih.gov/pubmed/25675656?dopt=Abstract</p>

IS - 4
J2 - Lepr Rev.
LA - eng
N2 - <div dir="ltr">Erythema nodosum leprosum (ENL) lesions may uncommonly develop ulceration, necrosis, pustulation or bullae. This 60year-old female was hospitalised with previously undiagnosed multibacillary (BL) leprosy and Sweet’s syndrome-like ENL, a presentation that is rarely reported. In addition to skin lesions simulating Sweet’s syndrome, she had anaemia, elevated ESR, and a peripheral leucocytosis with neutrophilia, the laboratory features of Sweet’s syndrome. The final diagnosis was made from chronic iridocyclitis, presence of lepra bacilli in slit-skin smears, and histology. The pathogenesis of Sweet’s-like ENL remains conjectural. In Sweet’s syndrome a complex interplay of various cytokines leading to an abundance of pro-inflammatory cytokines in the target tissues has been postulated to initiate an abnormal tissue response to certain antigens; such findings may eventually explain these uncommon lepra reactions as well.</div>

PY - 2014
SP - 322
EP - 327
T2 - Leprosy review
TI - Erythema nodosum leprosum mimicking Sweet’s syndrome: an uncommon presentation
UR - https://leprosyreview.org/article/85/4/32-2327
VL - 85
ER -