TY - JOUR
KW - Multi drug therapy
KW - leprosy
KW - Clinical trial
KW - Brazil
AU - Penna MLF
AU - Bührer-Sékula S
AU - Pontes MAA
AU - Cruz R
AU - De Sa Concalves H
AU - Penna GO
AB - <div dir="ltr">Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment allowing uniformity in treatment for all cases renders case classification superfluous and therefore simplifies leprosy control.</div>

<div dir="ltr">Objective: To evaluate the association between treatment duration and the trend in bacteriological index (BI) decrease over time among patients given Uniform MDT (UMDT) compared to those given regular MDT (RMDT).</div>

<div dir="ltr">Methods: An open-label randomised clinical trial to compare the present routine treatment with one lasting six month. Patient intake was from March 2007 to February 2012. To evaluate the trend of BI as a function of time, a multilevel linear with mixed effects model was fixed to the two study groups and also four groups after stratification by BI, less than 3 and 3 or more.</div>

<div dir="ltr">Results: The BI fall was higher among those taking RMDT, this difference however was not statistically significant.</div>

BT - Leprosy review
C1 - <p>http://www.ncbi.nlm.nih.gov/pubmed/25675650?dopt=Abstract</p>

IS - 4
J2 - Lepr Rev.
LA - eng
N2 - <div dir="ltr">Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment allowing uniformity in treatment for all cases renders case classification superfluous and therefore simplifies leprosy control.</div>

<div dir="ltr">Objective: To evaluate the association between treatment duration and the trend in bacteriological index (BI) decrease over time among patients given Uniform MDT (UMDT) compared to those given regular MDT (RMDT).</div>

<div dir="ltr">Methods: An open-label randomised clinical trial to compare the present routine treatment with one lasting six month. Patient intake was from March 2007 to February 2012. To evaluate the trend of BI as a function of time, a multilevel linear with mixed effects model was fixed to the two study groups and also four groups after stratification by BI, less than 3 and 3 or more.</div>

<div dir="ltr">Results: The BI fall was higher among those taking RMDT, this difference however was not statistically significant.</div>

PY - 2014
SP - 262
EP - 266
T2 - Leprosy review
TI - Results from the clinical trial of uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Decrease in bacteriological index.
UR - https://leprosyreview.org/article/85/4/26-2266
VL - 85
ER -