TY - JOUR
KW - leprosy
KW - Therapeutics
KW - Disabled Persons
KW - Mycobacterium leprae
KW - Nerve Degeneration
KW - Epidemiology
AU - Ribeiro de Araújo e Araújo AE
AU - Aquino DMC
AU - Goulart IMB
AU - Pereira SRF
AU - Figueiredo I
AU - Serra HO
AU - Almeida Fonseca PC
AU - Jesus Mendes Caldas A
AB - Introduction: Leprosy is an infectious disease whose etiologic agent is Mycobacterium leprae, manifested
by dermatological and neurological signs and symptoms. Objective: To investigate neural changes and the degree of
physical disability in the eyes, hands and feet before and after treatment, as well as sociodemographic and clinical
profile of patients affected by leprosy. Method: A longitudinal epidemiological study comprising 155 patients with
leprosy, from a spontaneous demand, diagnosed between March 2010 and February 2011, and treated with multidrug
therapy (MDT) between March 2010 and July 2012 in a program for leprosy eradication in São Luis (MA), Brazil.
Results: Before treatment, 46.5% of patients were considered as borderline, 51.6% had some alteration in the
eyes and 52.3% in the feet, and the radial nerve (18.7%) was the most affected. There was a statistically significant
difference between the changes in the radial nerve at the beginning of and after treatment. Conclusions: The analysis
points to late diagnosis, as some patients have had abnormal neural and physical disabilities before treatment.
BT - Revista Brasileira de Epidemiologia
DO - 10.1590/1809-4503201400040009
IS - 4
J2 - Rev. bras. epidemiol.
LA - por
N2 - Introduction: Leprosy is an infectious disease whose etiologic agent is Mycobacterium leprae, manifested
by dermatological and neurological signs and symptoms. Objective: To investigate neural changes and the degree of
physical disability in the eyes, hands and feet before and after treatment, as well as sociodemographic and clinical
profile of patients affected by leprosy. Method: A longitudinal epidemiological study comprising 155 patients with
leprosy, from a spontaneous demand, diagnosed between March 2010 and February 2011, and treated with multidrug
therapy (MDT) between March 2010 and July 2012 in a program for leprosy eradication in São Luis (MA), Brazil.
Results: Before treatment, 46.5% of patients were considered as borderline, 51.6% had some alteration in the
eyes and 52.3% in the feet, and the radial nerve (18.7%) was the most affected. There was a statistically significant
difference between the changes in the radial nerve at the beginning of and after treatment. Conclusions: The analysis
points to late diagnosis, as some patients have had abnormal neural and physical disabilities before treatment.
PY - 2014
SP - 899 
EP -  910
T2 - Revista Brasileira de Epidemiologia
TI - [Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity] 
TT - Complicações neurais e incapacidades em hanseníase em capital do nordeste brasileiro com alta endemicidade
UR - http://www.scielo.br/pdf/rbepid/v17n4/pt_1415-790X-rbepid-17-04-00899.pdf
VL - 17
ER -