TY - JOUR
KW - Borderline leprosy
KW - leprosy
KW - Brazil
AU - Jarduli LR
AU - Alves HV
AU - Marcos E
AU - Souza F
AU - Pereira AC
AU - Mira MT
AU - Moraes M
AU - Visentainer J
AB - Introduction
The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy.
Methods
The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher’s exact test and stepwise multivariate analysis.
Results
There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female is a protective factor against the development of the disease per se and the more severe clinical form.
Conclusions
This study showed that activating and inhibitory KIR genes may influence the development of leprosy – in particular, activating genes may protect against the more aggressive form of the disease – thereby demonstrating the role of NK cells in the immunopathology of the disease.
BT - Human Immunology
DO - 10.1016/j.humimm.2014.08.172
LA - eng
N2 - Introduction
The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy.
Methods
The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher’s exact test and stepwise multivariate analysis.
Results
There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female is a protective factor against the development of the disease per se and the more severe clinical form.
Conclusions
This study showed that activating and inhibitory KIR genes may influence the development of leprosy – in particular, activating genes may protect against the more aggressive form of the disease – thereby demonstrating the role of NK cells in the immunopathology of the disease.
PY - 2014
EP - 127
ST - Human Immunology
T2 - Human Immunology
TI - KIR GENES AND HLA LIGANDS IN THE PATHOGENESIS OF LEPROSY IN A HYPERENDEMIC POPULATION OF SOUTHERN BRAZIL
VL - 75
SN - 01988859
ER -