Background: Leprosy presents itself in different clinico-pathological forms, depending on the immune status of the host. The study of pathological changes in leprosy lesions has contributed a great deal to understand the disease and clinico-pathological correlative studies have provided further insights into the disease, it’s varied manifestations and complications.
Objective: The study was undertaken to correlate different types of leprosy clinically and histopathologically.
Materials and Methods: A total of 100 leprosy skin biopsies were studied over a period of 24 months between 2004 and 2006. Biopsies were fixed in 10% formalin and processed. 5 μ sections were stained with hematoxylin and eosin and modified Fite Farraco for lepra bacilli. Subsequently clinical and the histopathological correlation was studied using Ridley–Jopling classification.
Results: The majority of patients were in the age group of 20-29 years (30%). There were 80 (80%) males and 20 (20%) females. Overall clinicopathological correlation was observed in 65% of cases. The correlation was highest in indeterminate leprosy (81.81%) followed by lepromatous leprosy (78.57%), borderline lepromatous leprosy (70%), borderline tuberculoid (64.28%), mid borderline (55.55%) and tuberculoid (42.85%).
Conclusion: The histopathological features in leprosy indicate the accurate response of the tissues while the clinical features indicate only the gross morphology of the lesions caused by the underlying pathological change. Since tissue response varies in the disease spectrum, because of the variability of cell-mediated immunity, it is logical to expect some disparity between the clinical and histopathological features. For accurate typing of leprosy, correlation of clinical and histopathological features along with bacteriological examination appears to be more useful than considering any of the single parameters alone.
BT - International Journal of Scientific Study IS - 1 J2 - Int J Sci Stud LA - eng N2 -
Background: Leprosy presents itself in different clinico-pathological forms, depending on the immune status of the host. The study of pathological changes in leprosy lesions has contributed a great deal to understand the disease and clinico-pathological correlative studies have provided further insights into the disease, it’s varied manifestations and complications.
Objective: The study was undertaken to correlate different types of leprosy clinically and histopathologically.
Materials and Methods: A total of 100 leprosy skin biopsies were studied over a period of 24 months between 2004 and 2006. Biopsies were fixed in 10% formalin and processed. 5 μ sections were stained with hematoxylin and eosin and modified Fite Farraco for lepra bacilli. Subsequently clinical and the histopathological correlation was studied using Ridley–Jopling classification.
Results: The majority of patients were in the age group of 20-29 years (30%). There were 80 (80%) males and 20 (20%) females. Overall clinicopathological correlation was observed in 65% of cases. The correlation was highest in indeterminate leprosy (81.81%) followed by lepromatous leprosy (78.57%), borderline lepromatous leprosy (70%), borderline tuberculoid (64.28%), mid borderline (55.55%) and tuberculoid (42.85%).
Conclusion: The histopathological features in leprosy indicate the accurate response of the tissues while the clinical features indicate only the gross morphology of the lesions caused by the underlying pathological change. Since tissue response varies in the disease spectrum, because of the variability of cell-mediated immunity, it is logical to expect some disparity between the clinical and histopathological features. For accurate typing of leprosy, correlation of clinical and histopathological features along with bacteriological examination appears to be more useful than considering any of the single parameters alone.
PY - 2015 SP - 94 EP - 98 T2 - International Journal of Scientific Study TI - Clinico-Histopathological Study of Leprosy UR - http://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_apr_oa20.pdf VL - 3 ER -